艾美捷ALC-0159是聚乙二醇化脂质,已用于形成脂质纳米颗粒以递送RNA。除了ALC-0315、DSPC和胆固醇外,ALC-0159是针对SARS-CoV-2的BNT162b2疫苗的成分之一。这是一种试剂级产品,仅供研究使用。
艾美捷ALC-0159基本参数:
规格:10MG/25M/5MG/50MG
CAS编号:1849616-42-7
分子式:(C2H4O)nC31H63NO2
分子量(g/mol):~2330
纯度:>95%
存储:-20°C或以下
类别:脂类
滤器:电离/阳离子脂质
艾美捷ALC-0159参考文献:
1) R. Tenchov, R. Bird, A. E. Curtze, Q. Zhou (2021) “Lipid Nanoparticles—From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement” ACS Nano, DOI: 10.1021/acsnano.1c04996.
2) K.H. Moss, P. Popova, et al. (2019) “Lipid Nanoparticles for Delivery of Therapeutic RNA Oligonucleotides” Mol. Pharmaceutics 16, 2265–2277, DOI: 10.1021/acs.molpharmaceut.8b01290.
3) Y. Duan, A. Dhar, et al. (2020) “A brief review on solid lipid nanoparticles: part and parcel of contemporary drug delivery systems” RSC Adv.,10, 26777-26791.
相关研究:
ALC-0315 N-1020
DSPE (18:0/18:0 PE) L-2118
Cholesterol L-6012
DSPC (18:0/18:0 PC) L-1118