GEO数据库https://www.ncbi.nlm.nih.gov/gds/
GEO DataSets和GEO Profiles是NCBI的Entrez数据库网络的一部分。与这些其他数据库一样，只需在GEO DataSets或GEO Profiles的搜索框中输入关键词，就可以找到感兴趣的数据。在GEO DataSets和GEO Profiles页面头部链接的高级搜索和限制页面，对复杂查询的构建有很大帮助。要构建一个复杂的查询，指定搜索条件、它们的字段，以及使用以下语法对条件进行布尔运算。
term [field] OPERATOR term [field]
注：OPERATOR is the Boolean operator ('AND', 'OR', 'NOT' must be capitalized).
常用字段为：
All Fields，Title，MeSH Terms，Description，Number of Samples，Supplementary Files，Update Date，GEO Accession，Organism
| Search by... | Search text |
|---|---|
| Free text | smoking cancer |
| Keywords and species | (smok* OR diet) AND (mammals[organism] NOT human[organism]) |
| Studies in the NIH Roadmap Epigenomics project | "roadmap epigenomics"[Project] |
| Study type | "expression profiling by high throughput sequencing"[DataSet Type] |
| Studies with between 100 and 500 samples | 100:500[Number of Samples] |
| Studies with CEL files | "cel"[Supplementary Files] |
| DataSets that have 'age' as an experimental variable | "age"[Subset Variable Type] |
| Author | smith a[Author] |
| Published between January and June 2007 | 2007/01:2007/06[Publication Date] |
| Platform accession | GPL570 |
| Studies with PubMed identifiers | "gds pubmed"[Filter] |
关于MeSH https://www.nlm.nih.gov/mesh/meshhome.html
例子
gastric tumor[MeSH]
gastric tumor[Title]
gastric tumor[Title] AND Homo sapiens[Organism]
Colorectal Neoplasms[MeSH]
Colorectal Neoplasms[MeSH] AND Homo sapiens[Organism]
Colorectal Neoplasms[MeSH] AND Homo sapiens[Organism] AND 100:500[Number of Samples] AND
Colorectal cancer[All Fields] AND Homo sapiens[Organism]
Colorectal cancer[MeSH Terms] AND "Homo sapiens"[Organism]
(survival OR prognosis OR prognostic OR outcome OR death OR relapse OR recurrence) AND Colorectal Neoplasms[MeSH] AND Homo sapiens[Organism] AND (metastatic OR metastasis) AND 10:10000[Number of Samples] AND GPL570[Related Series]
Colorectal Neoplasms[MeSH] AND immunotherapy[Title]
Colorectal Neoplasms[MeSH] AND primary[Title]
Colorectal Neoplasms[MeSH] AND primary[metastatic]
(intestinal polyps[MeSH] OR Colorectal Neoplasms[MeSH]) AND Homo sapiens[Organism] AND primary[Title] AND AND 10:10000[Number of Samples]
参考
https://www.ncbi.nlm.nih.gov/geo/info/qqtutorial.html