乙酰基六肽-1——促进黑色素合成，调节皮肤色素沉着

简介

促黑素细胞激素（melanocyte-stimulating hormone α, MSH-α）对黑素细胞有广泛的刺激效应，可刺激黑素细胞的分裂增殖，促进黑素细胞酪氨酸酶的表达，提高酪氨酸酶的活性，增加黑素的生物合成。MSH-α是一种内源性的神经肽，来源于其前体激素-阿黑皮素原（POMC）。MSH-α具有多种重要的生理功能，均由黑皮素受体介导。黑皮素-1受体（melanocortin-1 receptor, MC-1R）几乎在所有类型的皮肤细胞中表达，其中在皮肤黑素细胞和角质形成细胞为最高表达。MC-1R促黑素生成作用是通过与MSH-α和ACTH结合后，经腺苷酸环化酶来提高环磷酸腺苷（cAMP）的水平，从而增强酪氨酸酶的活性，刺激黑素细胞分化、增殖，促进黑色素合成。同时MC-1R在调节皮肤色素沉着方面起控制作用。

brief introduction
Melanocyte stimulating hormone α,  MSH- α） It has a wide range of stimulating effects on melanocytes, which can stimulate the division and proliferation of melanocytes, promote the expression of tyrosinase in melanocytes, increase the activity of tyrosinase, and increase the biosynthesis of melanin. MSH- α It is an endogenous neuropeptide derived from its precursor hormone, proopiomelanocortin (POMC). MSH- α It has multiple important physiological functions, all mediated by melanocortin receptors. Melanocortin-1 receptor (MC-1R) is expressed in almost all types of skin cells, with the highest expression observed in skin melanocytes and keratinocytes. MC-1R promotes melanogenesis by interacting with MSH- α After binding with ACTH, adenosine cyclase is used to increase the level of cyclic adenosine monophosphate (cAMP), thereby enhancing the activity of tyrosinase, stimulating melanocyte differentiation and proliferation, and promoting melanin synthesis. Meanwhile, MC-1R plays a controlling role in regulating skin pigmentation.

INCI 名称 乙酰基六肽-1

机理

乙酰基六肽-1促进皮肤色素沉着和黑色素生成，增强皮肤对紫外线的抵抗能力。

乙酰基六肽-1保护和修复紫外线对DNA的损伤

乙酰基六肽-1降低紫外照射引起的炎症反应，减少皮肤红斑

美容功效

乙酰基六肽-1激活α-促黑素细胞激素，促进黑色素合成；加速头发色素沉积，逆转白化过程；诱导皮肤色素沉积；增强皮肤对抗有害紫外线的抵抗力；减少皮肤红斑；保护和修复由于紫外线照射引起的DNA损伤；减少炎症反应。